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John F Smyth Selected Research

NU-ICRF 505

1/2004Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins.
2/2002Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation.

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John F Smyth Research Topics

Disease

20Ovarian Neoplasms (Ovarian Cancer)
01/2012 - 04/2002
15Neoplasms (Cancer)
01/2012 - 04/2002
5Ovarian Epithelial Carcinoma
09/2008 - 04/2002
4Neoplasm Metastasis (Metastasis)
04/2012 - 12/2005
3Carcinoma (Carcinomatosis)
08/2005 - 12/2002
3Colorectal Neoplasms (Colorectal Cancer)
02/2004 - 02/2002
3Colonic Neoplasms (Colon Cancer)
01/2004 - 02/2002
1Melanoma (Melanoma, Malignant)
04/2012
1Inflammation (Inflammations)
01/2012
1Brain Neoplasms (Brain Tumor)
12/2010
1Ascites
10/2009
1Myalgia
05/2008
1Lymphoma (Lymphomas)
05/2008
1Disease Progression
06/2007
1Breast Neoplasms (Breast Cancer)
01/2004
1Adenocarcinoma
11/2002

Drug/Important Bio-Agent (IBA)

7Proteins (Proteins, Gene)FDA Link
10/2009 - 04/2002
5Letrozole (Femara)FDA LinkGeneric
09/2008 - 07/2002
5Estrogen ReceptorsIBA
09/2007 - 07/2002
5Messenger RNA (mRNA)IBA
09/2007 - 12/2002
4Aromatase InhibitorsIBA
09/2007 - 07/2002
4Topoisomerase I InhibitorsIBA
01/2004 - 02/2002
3ParaffinIBA
09/2007 - 07/2002
3Estrogens (Estrogen)FDA Link
09/2007 - 12/2005
3ErbB Receptors (EGF Receptor)IBA
08/2005 - 07/2002
3Irinotecan (Camptosar)FDA LinkGeneric
01/2004 - 02/2002
3Pharmaceutical PreparationsIBA
01/2004 - 07/2003
2CytokinesIBA
01/2012 - 10/2009
2Small Interfering RNA (siRNA)IBA
01/2012 - 06/2009
2Progesterone Receptors (Progesterone Receptor)IBA
03/2010 - 07/2002
2Biomarkers (Surrogate Marker)IBA
09/2008 - 07/2002
2Indicators and Reagents (Reagents)IBA
09/2007 - 03/2007
2Transforming Growth Factor alpha (TGF-alpha)IBA
01/2007 - 03/2005
2Protein Isoforms (Isoforms)IBA
04/2006 - 12/2002
2PlatinumIBA
08/2005 - 11/2002
2Cisplatin (Platino)FDA LinkGeneric
08/2005 - 11/2002
2NU-ICRF 505IBA
01/2004 - 02/2002
2Uridine Diphosphate (UDP)IBA
01/2004 - 12/2003
2Type I DNA Topoisomerases (Topoisomerase I)IBA
07/2003 - 02/2002
1Galectin 3 (LGALS3)IBA
04/2012
1ChemokinesIBA
01/2012
1Neutralizing AntibodiesIBA
01/2012
1Interleukin-6 (Interleukin 6)IBA
01/2012
1AntibodiesIBA
01/2012
1Biological ProductsIBA
12/2010
1AntigensIBA
12/2010
1Interleukin-23 (Interleukin 23)IBA
10/2009
1Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
10/2009
1Transforming Growth Factor beta1 (TGF beta 1)IBA
10/2009
1Interleukin-17 (Interleukin 17)IBA
10/2009
1Type I Tumor Necrosis Factor ReceptorsIBA
10/2009
1Infliximab (Remicade)FDA Link
10/2009
1NF-kappa B (NF-kB)IBA
10/2009
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2009
1Integrin alpha3IBA
06/2009
1matrigelIBA
06/2009
1WW Domain-Containing OxidoreductaseIBA
06/2009
1Fibronectins (Fibronectin)IBA
06/2009
1Hormones (Hormone)IBA
09/2008
1Creatine Kinase (Creatine Phosphokinase)IBA
05/2008
1plitidepsin (aplidine)IBA
05/2008
1EnzymesIBA
05/2008
1Aromatase (CYP19)IBA
09/2007
1Estrogen Receptor Modulators (Antiestrogen)IBA
06/2007
1Insulin-Like Growth Factor Binding ProteinsIBA
03/2007
1Insulin-Like PeptidesIBA
03/2007
1pertuzumabIBA
01/2007
1heregulin beta1IBA
01/2007
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
04/2006
1Complementary DNA (cDNA)IBA
12/2005
1Estrogen Receptor betaIBA
12/2005
1Estrogen Receptor alphaIBA
12/2005
1Cell Adhesion MoleculesIBA
08/2005
1Phospholipase C gammaIBA
03/2005
1Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
03/2005
1ISIS 5132IBA
03/2004
1Antisense OligonucleotidesIBA
03/2004
1DNA (Deoxyribonucleic Acid)IBA
02/2004
1Oxaliplatin (Eloxatin)FDA LinkGeneric
02/2004
1GlucuronidesIBA
01/2004
1ATP-Binding Cassette Sub-Family B Member 4IBA
01/2004
1Carrier Proteins (Binding Protein)IBA
01/2004
1multidrug resistance-associated protein 1IBA
01/2004
1Glycoproteins (Glycoprotein)IBA
01/2004
1IsoenzymesIBA
12/2003
1Food Additives (Food Additive)IBA
12/2003
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
12/2003
1NeuregulinsIBA
12/2002
1matriptaseIBA
04/2002
1HGF activatorIBA
04/2002
1Serine Proteases (Serine Protease)IBA
04/2002
1AnthraquinonesIBA
02/2002
1trioctyl phosphine oxide (TOPO)IBA
02/2002
1Tyrosine (L-Tyrosine)FDA Link
02/2002

Therapy/Procedure

7Therapeutics
09/2008 - 11/2002
5Drug Therapy (Chemotherapy)
08/2005 - 11/2002
1Intravenous Infusions
05/2008